the effects of the Jihad by this time that there was htfle de mand for the kind of simplistic technology most Bezelmn products represented Their popularity remained high until 10769 when the pistols were included in one of the earliest weaponry bans issued as part of Leto's Peace Further references LOTS Karden The Flame and the Flower A Short History of the Builerian Jihad (Yorba Rose) MELANGE (spice) [The following entries on melange appear to have been independent re ports (RRC NS 2 12 and RRC NS 2 13) Commissioned by the Bene Gesserit m the early days of the reign ofLeto II -Ed } BIOLOGICAL ACTIVITY A complex bio-polymer originating only on Arrakis Its sev eral biological activities include interaction with various centers of the central nervous system (CNS) interaction with the immune system and deposition within the sclera of the eyes To date the structure of the bio logically active portion of spice has not been isolated although it is known that other portions of the molecule contain gly coprotem a cuprit heme and cmnamic acid The interaction with the CNS is primarily in the Kohhker Kramptz center which con trols time space awareness In most humans this center is rudimentary consisting of only a small number of cells (K K cells) in the 375 central cortex of the brain Ingestion of spice stimulates the growth of K-K cells so that the individual becomes more aware of his/her time-space environment It is due to the action of the spice on the K-K cells that melange is addictive If quantities in excess of 2 grams daily per 70 kilograms of body weight are ingested, severe addiction is encountered Withdrawal from the spice from an addict results in insanity and eventual death due to the action of the breakdown products of K-K cells on the other cells of the CNS Bene Gessent research suggests that fe males capable of becoming Reverend Mothers have inherently well-developed Kohliker-Kramptz centers One theory proposed is that some component of the Konhkef-Kramptz center is genetically sex-linked If mat is true, then it is probable that Paul Atreides represented a mutation in drat component rather that a true product of the B G breed ing program Tins deviation is one explanation for the unique action of spice on the Atreides family Precedent has been set for mutation in the genes controlling the Kohliker Kramptz center The Guild Steersmen were manipulated genetically so that they had high ly developed Kohliker-Kramptz centers, al though originally their genetic engineers did not know the exact location or composition of the time-space awareness center The geriatric properties of melange are considerable The addict's predicted life-span is increased two to four time& that of normal, depending upon die age at which the spice was first ingested as well as the dose When the spice is digested, certain as yet unidentified breakdown products arc absorbed into the bloodstream These products interact with T cells of the immune syst